In September 2014, investigators reported that non-caloric artificial sweeteners alter gut flora and promote glucose intolerance. According to the National Household Nutritional Survey 2004, 15% of the population regularly use artificial sweeteners. Consumer Reports stated that 65% of American households bought at least one sucralose-containing product in 2008
The investigators evaluated 381 non-diabetic subjects for artificial sweetener intake, blood sugar metabolism, and gut microbiota. The researchers determined that the subjects who consumed the greatest amount of artificial sweeteners had higher fasting glucose levels, poorer glucose tolerance, and altered gut microbe profiles compared to the subjects that did not consume artificial sweeteners.
The researchers stated, "Collectively, our results link non-caloric artificial sweeteners consumption, dysbiosis, and metabolic abnormalities, thereby calling for a reassessment of massive non-caloric artificial sweeteners usage."
Reference:
Suez J, et al. Nature. 2014;514:181-6.